New population-based Danish cohort study out in Gut journal on antibiotics treatments during pregnancy and risk of ulcerative colitis in offspring:
Agrawal M, Poulsen G, Colombel J-F, Allin KH, Jess T. Maternal antibiotic exposure during pregnancy and risk of IBD in offspring: a population-based cohort study.
Early life exposures are important in regulating the microbiome and immune system, and risk of future diseases, such as inflammatory bowel disease (IBD). Antibiotics, especially increasing courses, can lead to sustained gut microbiome changes. In this population-based cohort study, we found that three or more courses, but nor fewer courses, of antibiotics during pregnancy are associated with increased ulcerative colitis (a subtype of IBD) risk by 45%. These data can help with clinical decision-making during pregnancy and help understand IBD risk factors and pathways.